What are Basophila & Mast Cell – Normal Range & Low High Count

Presentation notes on BASOPHILS & MAST Cells Structure, Similarity & Function in Human Blood in for medical & Biology Students in word / .doc / ppt format


Basophils have a diameter of 10-12 μ. Its nucleus is often 'S' shaped, cytoplasm contains coarse basophilic granules which (ie, the granules) appear to be over the nucleus. In the tissues there is a kind of cell called mast cells. Mast cells and , basophils are remarkably similar in appearance. Both mast cells and the basophils of blood contain histamine and heparin in their granules. When provoked, the mast cells or blood basophils degranulate and release histamine.

Mast cells

Mast cells are found in the connective tissues and brain but not in the blood. In many ways they are similar to the blood basophils. Thus, mast cells and blood basophils look almost identical; mast cells, contain basophilic granules containing histamine and heparin, when provoked (eg, penicillin injection in the susceptible person), the mast cells degranulate, release histamine; gross release of histamine causes anaphylactic shock, characterized by arteriolar dilatation (= fall of BP) and bronchospasm (= dyspnea) which can cause death. Heparin has effects on lipid metabolism and blood coagulation. (Incidentally, histamine is found, outside mast cells or basophils too - the 'non mast cell histamine' in brain).

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